Intermediate Filaments as Histologic Markers: An Overview
نویسندگان
چکیده
منابع مشابه
Intermediate filaments
Intermediate filaments form a class of insoluble cytoplasmic filaments ofdimensions intermediate in size between those of microtubules (about 25 nm in diameter) and microfilaments (about 7 nm in diameter). Thus, they are generally known as intermediate-sized filaments (IF)' or 10-nm filaments. They have been identified in virtually all differentiated types ofcells and it seems possible that IF-...
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Neurofilaments (NFs) are the most abundant structural components in large-diameter myelinated axons. Assembled as obligate heteropolymers requiring NF-L and substoichiometric amounts of NF-M and/or NF-H, NF investment into axons is essential for establishment of axonal caliber, itself a key determinant of conduction velocity. Use of transgenic mice to increase axonal accumulation of NFs or to e...
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In this chapter, we deal with the current knowledge and important results on the cyto‐ skeletal proteins and their differential regulation by kinases/phosphatases and Ca2+‐ mediated mechanisms in developmental rat brain. We focus on the misregulation of the phosphorylating system associated with intermediate filament proteins of neural cells and its relevance to cell and tissue dysfunction. Tak...
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The intermediate filament (IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimentin or desmin impairs contractile ability of various smooth muscle preparations, implying their important role for smooth muscle force development. The IF framework ha...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1983
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12540811